Search scope:
排序: Display mode:
Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient
Frontiers of Medicine 2022, Volume 16, Issue 1, Pages 150-155 doi: 10.1007/s11684-021-0846-5
Keywords: cystic fibrosis CFTR splicing mutation minigene
Alternative splicing of inner-ear-expressed genes
Yanfei Wang,Yueyue Liu,Hongyun Nie,Xin Ma,Zhigang Xu
Frontiers of Medicine 2016, Volume 10, Issue 3, Pages 250-257 doi: 10.1007/s11684-016-0454-y
Alternative splicing plays a fundamental role in the development and physiological function of theInner-ear-specific gene splicing is necessary to establish the identity and maintain the function of, exon 68 of Cadherin 23 (Cdh23) gene is subject to inner-ear-specific alternative splicingDifferential splicing of Kcnma1, which encodes for the α subunit of the Ca2+splicing have been shown to cause hearing loss, as we can observe
Keywords: alternative splicing inner ear hearing loss hair cells
lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis
Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 317-329 doi: 10.1007/s11684-022-0931-4
Keywords: lncR-GAS5 miR-193-5p splicing factor SRSF10 autophagy atherogenesis
Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott
Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2, Pages 186-195 doi: 10.1007/s11705-015-1540-4
Keywords: RNA splicing gene expression breast cancer DNA damage CHK1
Frontiers of Medicine Pages 907-923 doi: 10.1007/s11684-023-1009-7
Keywords: FAK6/7 SRRM4 neuroendocrine neoplasms pancreas breast
Mutation profiling of 16 candidate genes in
Yang Zhang, Fang Wang, Xue Chen, Wenjing Liu, Jiancheng Fang, Mingyu Wang, Wen Teng, Panxiang Cao, Hongxing Liu
Frontiers of Medicine 2019, Volume 13, Issue 2, Pages 229-237 doi: 10.1007/s11684-018-0616-1
Frontiers of Medicine 2022, Volume 16, Issue 4, Pages 627-636 doi: 10.1007/s11684-020-0815-4
Keywords: RUNX1 gene mutation acute myeloid leukemia transcriptional repression DNA methylation
Solving Knapsack Problem by Hybrid Particle Swarm Optimization Algorithm
Gao Shang,Yang Jingyu
Strategic Study of CAE 2006, Volume 8, Issue 11, Pages 94-98
Keywords: particle swarm algorithm knapsack problem genetic algorithm mutation
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice
Frontiers of Medicine Pages 957-971 doi: 10.1007/s11684-023-0988-8
Keywords: DNAH10 mice motile cilia mutation primary ciliary dyskinesia
Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang
Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 319-323 doi: 10.1007/s11684-017-0553-4
Keywords: antithrombin deficiency protein C activity mutation variant venous thromboembolism anticoagulants
Xuefei Ma, Wei Zhang, Rong Zhang, Jingming Li, Shufen Li, Yunlin Ma, Wen Jin, Kankan Wang
Frontiers of Medicine 2019, Volume 13, Issue 3, Pages 330-343 doi: 10.1007/s11684-017-0557-0
Keywords: long noncoding RNA CRNDE alternative splicing
Frontiers of Medicine doi: 10.1007/s11684-023-1016-8
Keywords: p53 mutation triple-negative breast cancer decitabine DNMT1 IRF7 innate immune response
Dual faces of SH2-containing protein-tyrosine phosphatase
Shuangwei Li, Diane DiFang Hsu, Hongyang Wang, Gen-Sheng Feng
Frontiers of Medicine 2012, Volume 6, Issue 3, Pages 275-279 doi: 10.1007/s11684-012-0216-4
PTPN11, which encodes tyrosine phosphatase Shp2, is a critical gene mediating cellular responses to hormones and cytokines. Against original prediction as tumor suppressor for tyrosine phosphatases, PTPN11 was first identified as a proto-oncogene because activating mutations of this gene are associated with leukemogenesis. However, most recent experimental data suggest PTPN11/Shp2 acting as a tumor suppressor in hepatocarcinogenesis. This review focuses on the tumor-promoting or suppressing roles of the gene PTPN11/Shp2 in different cell types.
Keywords: PTPN11/Shp2 leukemia hepatocellular carcinoma mutation
AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches
Megan A. Hatlen, Lan Wang, Stephen D. Nimer
Frontiers of Medicine 2012, Volume 6, Issue 3, Pages 248-262 doi: 10.1007/s11684-012-0206-6
The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is present in approximately 4%–12% of adult and 12%–30% of pediatric acute myeloid leukemia (AML) patients. Both human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesis in the absence of secondary events. In this review, we discuss the pathogenetic insights that have been gained from identifying the various events that can cooperate with AML1-ETO to induce AML in vivo. We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting the fusion protein itself, the proteins that bind to it, or the genes that it regulates. Recently published studies suggest that a targeted therapy for t(8;21) positive AML is feasible and may be coming sometime soon.
Keywords: AML1-ETO mouse model leukemia t(8 21) pathway hits mutation hematopoiesis Kasumi-1 CD34+
662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)
QU Yanchun, YANG Ze, SUN Liang, JI Linong
Frontiers of Medicine 2008, Volume 2, Issue 3, Pages 283-285 doi: 10.1007/s11684-008-0053-7
Keywords: D-HPLC mutation development autoimmune PCR-RFLP candidate
Title Author Date Type Operation
Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient
Journal Article
Alternative splicing of inner-ear-expressed genes
Yanfei Wang,Yueyue Liu,Hongyun Nie,Xin Ma,Zhigang Xu
Journal Article
lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis
Journal Article
Transformer2 proteins protect breast cancer cells from accumulating replication stress by ensuring productive splicing
Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott
Journal Article
High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas
Journal Article
Mutation profiling of 16 candidate genes in
Yang Zhang, Fang Wang, Xue Chen, Wenjing Liu, Jiancheng Fang, Mingyu Wang, Wen Teng, Panxiang Cao, Hongxing Liu
Journal Article
Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation in acute myeloid leukemia
Journal Article
Solving Knapsack Problem by Hybrid Particle Swarm Optimization Algorithm
Gao Shang,Yang Jingyu
Journal Article
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice
Journal Article
Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism: a case report
Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang
Journal Article
Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers
Xuefei Ma, Wei Zhang, Rong Zhang, Jingming Li, Shufen Li, Yunlin Ma, Wen Jin, Kankan Wang
Journal Article
Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational study
Journal Article
Dual faces of SH2-containing protein-tyrosine phosphatase
Shuangwei Li, Diane DiFang Hsu, Hongyang Wang, Gen-Sheng Feng
Journal Article
AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches
Megan A. Hatlen, Lan Wang, Stephen D. Nimer
Journal Article